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TSH Research GmbH MATERIALS SCIENCE.
MOLECULAR POSSIBILITIES.
Let’s talk science

A TOOLBOX OF NANOMATERIALS

Small particles.
Precise
chemistry.

A toolbox of inorganic and organic nanoparticles — and a perspective on oncolytic virus research. Connecting materials with your scientific questions.

Explore the toolbox
THREE RESEARCH AREAS
One scientific conversation.
RESEARCH, UP CLOSE01 / DIAMOND
Cy3 fluorescence in viable inflammatory macrophages during miRNA146 detection using diamond nanoparticles.
Molecular signals. Made visible.miRNA146 detection in viable inflammatory macrophages↗
THE TOOLBOX01 Inorganic ↗02 Organic ↗03 Oncolytic viruses ↗

01 / RESEARCH AREAS

Different approaches.
Connected by research.

From a reactive particle surface to a biological interaction. Find the starting point for your next experiment.

01 / RESEARCH AREAC / Fe₃O₄

Available for research

Inorganic nanoparticles

Surface-activated diamond and superparamagnetic magnetite core–shell particles. Explore the materials, coupling chemistry and microscopy.

Diamond & magnetite↗
02 / RESEARCH AREAEV

Research & development

Organic nanoparticles

A developing toolbox of organic nanomaterials, including extracellular vesicles. Explore our focus on exosomes and intercellular communication.

Exosomes & maple-syrup-based particles↗
03 / RESEARCH AREANDV

Research & development

Oncolytic viruses

Research into Newcastle Disease Virus for oncolytic applications. Explore the research focus and original cell-culture microscopy.

Newcastle Disease Virus↗

02 / SURFACE CHEMISTRY

The difference
is on the surface.

Our inorganic nano- and microparticles have a reactive surface for coupling molecules such as DNA, RNA, proteins and small molecules.

Explore the chemistry
01

Thiol & amino groups

Coupling at room temperature in water or near-neutral buffer.

WATER / NEAR-NEUTRAL BUFFER
02

Hydroxy groups

Coupling at elevated temperature in aprotic solvents.

ELEVATED TEMPERATURE
Fluorescence microscopy of 4–8 µm microdiamonds carrying a 20mer oligonucleotide, hybridized to a complementary Cy3-labelled sequence.
Original TSH microscopy · Cy3-labelled oligonucleotides on microdiamonds.
03 / FROM MATERIAL TO INTERACTION

A connection
you can see.

Surface chemistry provides the link between a particle and a molecule. Here, a 20mer oligonucleotide bound to 4–8 µm microdiamonds is visualised using its complementary Cy3-labelled sequence.

See the research examples

START A SCIENTIFIC CONVERSATION

What should your
particle do?

Tell us about the molecule you want to attach, the interaction you want to study, or the material you have in mind.

Let’s talk science